Suggested Use: 2 capsules per day, in divided doses, with meals.
This formula requires refrigeration after opening.
What Is It?
Homocysteine Factors provides activated vitamin B6 (pyridoxal 5-phosphate), vitamin B12, folate (Metafolin®, L-5-MTHF) and betaine, a highly bioavailable combination of nutrients integral to supporting healthy homocysteine levels and cardiovascular health.*
Uses For Homocysteine Factors
Cardiovascular Health: Clinical studies show that folate, vitamin B12, and vitamin B6 are vital in the metabolism of homocysteine. Vitamin B12 and folate are required by the enzyme that converts homocysteine back to methionine. Folate is provided in this formula as Metafolin®, the naturally occurring universally metabolized form of folate. Metafolin® is chemically identical to the active folate metabolite, 5-methyltetrahydrofolate (L-5-MTHF). L-5-MTHF is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations. Vitamin B6 is required in each of the two enzymatic reactions that convert homocysteine to cysteine. One of the major roles of betaine, also known as trimethylglycine, is in promoting healthy homocysteine metabolism. In a recent study, a betaine-rich diet or betaine supplementation supported healthy homocysteine metabolism in men and women. It is believed that betaine may be especially supportive when vitamin B12, folic acid and vitamin B6 are not sufficient to maintain healthy homocysteine levels.*
As part of a well-balanced diet that is low in saturated fat and cholesterol, folic acid, vitamin B6, and vitamin B12 may reduce the risk of vascular disease.† †The FDA evaluated the above claim and found that while it is known that diets low in saturated fat and cholesterol reduce the risk of heart disease and other vascular diseases, the evidence in support of the above claim is inconclusive.
What Is The Source?
Vitamin B12 is derived from microbiological fermentation. Vitamin B6 and folic acid (Metafolin®, L-5- MTHF) are synthetically produced. Betaine is originally derived from sugar beet molasses and undergoes an extensive purification process. Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and hypoallergenic plant fiber is derived from pine cellulose. Metafolin® is a registered Trademark of Merck KGaA, Darmstadt, Germany.
Pure Encapsulations recommends 2 capsules per day, in divided doses, with meals. This formula requires refrigeration after opening
Are There Any Potential Side Effects Or Precautions?
At this time, there are no known side effects or precautions. If pregnant or lactating, consult your physician before taking this product.
Are There Any Potential Drug Interactions?
Folic acid-containing supplements may interfere with methotrexate therapy in people with cancer.