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Suggested Use: 1-2 capsules per day, in divided doses, with meals.
B12 Folate – Pure Encapsulations offers B12 Folate, combining these two powerhouse B vitamins. B12 and folate work together to support the nervous system, cardiovascular system and is crucial for fetal neural development. This product feature Metafolin. An extensive body of evidence indicates that adequate folate intake may provide significant cardiovascular, cellular and neural protection. However, genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent. In line with our commitment to consistently offer innovative, science-based ingredients, Pure Encapsulations has updated a number of products†, including our multivitamins, to provide Metafolin® (L-5-MTHF). Metafolin® is a naturally occurring, universally metabolized and active form of folate, L-5-MTHF. As such, it can be directly used in a diverse array of essential methylation reactions to support cardiovascular, neural and emotional health. Additionally, clinical evidence indicates that the bioavailability of Metafolin® is superior to folic acid. In a double-blind, randomized, placebocontrolled intervention study of 144 women of child-bearing age, 5-MTHF supplementation resulted in a greater accumulation of 5-MTHF in red blood cells than equimolar doses of folic acid.
What Is It?
B12 Folate is a combination of two water-soluble B vitamins, folic acid and vitamin B12. Folic acid is provided in this formula as Metafolin®, the naturally occurring universally metabolized form of folate. Metafolin® is chemically identical to the active folate metabolite, 5-methyltetrahydrofolate (L-5-MTHF). L-5-MTHF is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations. The B12 in this formula is provided as methylcobalamin, the most bioavailable form of this vitamin.*
Uses For B12 Folate
Nutrient Metabolism: Folic acid and vitamin B12 are interrelated in function. They convert carbohydrates into energy and are vital in the metabolism of fats and protein. They play an important role in the maintenance of muscle tone in the GI tract and the integrity of skin, hair and the liver. They are also critical for maintaining red blood cell homeostasis and healthy homocysteine levels.*
Nervous System Health: Adequate folate status is critical for nucleic acid synthesis and neurotransmitter synthesis. At the molecular level, the main function of folate is to donate methyl groups in key biochemical reactions occurring in blood cells, neurons, the vasculature and many other tissues. In recent studies, methylcobalamin has demonstrated an enhanced ability to support neurological function. Vitamin B12 promotes protein synthesis for maintaining healthy nerve cells and myelin. Methylcobalamin may also help to moderate levels of glutamate in the brain, encouraging healthy brain cell activity, as well as memory, mood, and cognitive function. In general, vitamin B12 works with folate to promote DNA and red blood cell health.*
What Is The Source?
Metafolin®, L-5-methyltetrahydrofolate (L-5-MTHF) is synthetic. Methylcobalamin is produced from corn dextrose fermentation. Hypo-allergenic plant fiber is derived from pine cellulose. Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil. Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany.
Are There Any Potential Side Effects Or Precautions?
At this time, there are no known side effects or precautions. If pregnant or lactating, consult your physician before taking this product.
Are There Any Potential Drug Interactions?
Folic acid may adversely interact with chemotherapeutic drugs.
Product Ingredients
Supplement Facts:
Suggested Use: 1-2 capsules per day, in divided doses, with meals.
each vegetable capsule contains:
| Ingredients | AMT | %DV |
|---|---|---|
| methylcobalamin (B12) | 800 mcg. | - |
| folate (as Metafolin®, L-5-MTHF) | 800 mcg. | - |
| vitamin C. (as ascorbyl palmitate) | 2 mg | - |
Other Ingredients: -
(-) There is no %DV or the manufacturer has not provided this data.
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—Dr. Devin Ryerson
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